| Gene Symbol | EIF4A2 |
|---|---|
| Entrez Gene | 1974 |
| Alt Symbol | BM-010, DDX2B, EIF4A, EIF4F, eIF-4A-II, eIF4A-II |
| Species | Human |
| Gene Type | protein-coding |
| Description | eukaryotic translation initiation factor 4A2 |
| Other Description | ATP-dependent RNA helicase eIF4A-2|eukaryotic initiation factor 4A-II |
| Swissprots | Q53XJ6 Q14240 Q96EA8 D3DNU9 Q96B90 |
| Accessions | EAW78172 EAW78173 EAW78174 EAW78175 EAW78176 EAW78177 EAW78178 Q14240 AB209021 BAD92258 AF208852 AAF64266 AK130087 AK225646 AK296279 BAG58988 AL117412 CAI46218 AL137681 AL556981 AY207392 AAO66460 BC006469 BC012547 AAH12547 BC013708 AAH13708 BC015842 AAH15842 BC016295 AAH16295 BC039344 BC048105 AAH48105 BT009860 AAP88862 D30655 BAA06336 DQ891738 ABM82664 DQ894914 ABM85840 S79942 NM_001967 NP_001958 |
| Function | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. |
| Top Pathways | RNA transport |