| Gene Symbol | Chst7 |
|---|---|
| Entrez Gene | 60322 |
| Alt Symbol | 2600013M07Rik, C6ST-2, GST5, Gn6st-4 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | carbohydrate (N-acetylglucosamino) sulfotransferase 7 |
| Other Description | GST-5|N-acetylglucosamine 6-O-sulfotransferase 1|N-acetylglucosamine 6-O-sulfotransferase 4|carbohydrate sulfotransferase 7|chondroitin 6-sulfotransferase 2|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5|glcNAc6ST-4|mC6ST-2 |
| Swissprots | Q9EP78 Q99NB0 |
| Accessions | AAG48247 EDL00760 EDL00761 Q9EP78 AB040710 BAB13769 AB046929 BAB40372 AK011202 BAB27465 BC019204 AAH19204 XR_878032 NM_021715 NP_068361 |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N- acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc. {ECO:0000269|PubMed:10913333}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Widely expressed. Highly expressed in kidney. Expressed at lower level in heart, lung and liver. {ECO:0000269|PubMed:10913333}. |
| Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |