RHO1

Gene Symbol RHO1
Entrez Gene 856294
Alt Symbol -
Species Yeast
Gene Type protein-coding
Description Rho family GTPase RHO1
Other Description -
Swissprots P06780 D6W4G6
Accessions DAA11582 P06780 NM_001184262 NP_015491
Function Acts as a central regulator in the cell wall integrity signaling pathway, which is regulated by the cell cycle and in response to various types of cell wall stress. Integrates signals from different cell surface sensors, and activates a set of effectors, regulating processes including beta-glucan synthesis at the site of wall remodeling, gene expression related to cell wall biogenesis, organization of the actin cytoskeleton, and protein- and secretory vesicle-targeting to the growth site. Activates the protein kinase C (PKC1) MAP kinase cascade, the beta-1,3-glucan synthase (FKS1), the formin BNI1, the exocyst component SEC3 and the transcription factor SKN7. {ECO:0000269|PubMed:11283608, ECO:0000269|PubMed:11447600, ECO:0000269|PubMed:12207708, ECO:0000269|PubMed:12419188, ECO:0000269|PubMed:12810699, ECO:0000269|PubMed:12928491, ECO:0000269|PubMed:15514049, ECO:0000269|PubMed:15596542, ECO:0000269|PubMed:7579704, ECO:0000269|PubMed:8195291, ECO:0000269|PubMed:8602514, ECO:0000269|Pub
Subcellular Location Cell membrane; Lipid-anchor. Endosome membrane; Lipid-anchor. Peroxisome membrane; Lipid-anchor. Note=Plasma membrane-associated at sites of polarized growth such as incipient bud sites, bud tips, the bud neck during cytokinesis, and the neck and tip of mating projections. Also found on internal membranes of endosomes and peroxisomes.
Top Pathways Endocytosis, MAPK signaling pathway - yeast