| Gene Symbol | CMA1 |
|---|---|
| Entrez Gene | 1215 |
| Alt Symbol | CYH, MCT1, chymase |
| Species | Human |
| Gene Type | protein-coding |
| Description | chymase 1, mast cell |
| Other Description | alpha-chymase|chymase|chymase 1 preproprotein transcript E|chymase 1 preproprotein transcript I|chymase, heart|chymase, mast cell|mast cell protease I |
| Swissprots | Q9UDH5 Q3SY36 Q16018 Q3SY37 B5BUM8 P23946 |
| Accessions | AAA52020 AAA52021 CAA41796 EAW66007 P23946 AB451464 BAG70278 BC069110 AAH69110 BC069370 AAH69370 BC069490 AAH69490 BC103974 AAI03975 BC103975 AAI03976 DQ082727 AAZ06432 DQ082729 AAZ06434 HY275608 M69136 AAA52019 S61334 AAB26828 XM_011536394 XP_011534696 NM_001308083 NP_001295012 NM_001836 NP_001827 |
| Function | Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. |
| Subcellular Location | Secreted. Cytoplasmic granule. Note=Mast cell granules. |
| Tissue Specificity | Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions. {ECO:0000269|PubMed:8144971}. |
| Top Pathways | Renin-angiotensin system |