| Gene Symbol | EPHA7 |
|---|---|
| Entrez Gene | 2045 |
| Alt Symbol | EHK-3, EHK3, EK11, HEK11 |
| Species | Human |
| Gene Type | protein-coding |
| Description | EPH receptor A7 |
| Other Description | EPH homology kinase 3|EPH-like kinase 11|Eph homology kinase-3|ephrin type-A receptor 7|receptor protein-tyrosine kinase HEK11|tyrosine-protein kinase receptor EHK-3 |
| Swissprots | B7ZLJ9 Q8N368 A0AUX7 Q15375 Q5VTU0 Q59G40 B2R8W1 B7ZLK0 Q9H124 |
| Accessions | CAT16938 CCQ43263 EAW48518 EAW48519 EAW48520 EAW48521 Q15375 AB209269 BAD92506 AK313529 BAG36308 AL699163 BC027940 AAH27940 BC126125 AAI26126 BC126151 AAI26152 BC143857 AAI43858 BC143858 AAI43859 BM677016 DA503795 L36642 AAA74243 XM_005248669 XP_005248726 XM_005248671 XP_005248728 NM_001288629 NP_001275558 NM_001288630 NP_001275559 NM_004440 NP_004431 |
| Function | Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of E |
| Subcellular Location | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Tissue Specificity | Widely expressed. |
| Top Pathways | Axon guidance |