| Gene Symbol | CDKN1A |
|---|---|
| Entrez Gene | 1026 |
| Alt Symbol | CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| Other Description | CDK-interacting protein 1|CDK-interaction protein 1|DNA synthesis inhibitor|cyclin-dependent kinase inhibitor 1|melanoma differentiation associated protein 6|wild-type p53-activated fragment 1 |
| Swissprots | Q9BUT4 Q14010 Q6FI05 P38936 |
| Accessions | AAM11787 CAJ98559 CAJ98560 CBX54345 EAX03904 EAX03905 EAX03906 EAX03907 P38936 AA534613 AB209881 BAD93118 AB451290 BAG70104 AB451422 BAG70236 AI973138 AK298901 BAG61011 AK309512 AM392711 CAL37589 AM392920 CAL37798 BC000275 AAH00275 BC000312 AAH00312 BC001935 AAH01935 BC013967 AAH13967 BQ941282 BT006719 AAP35365 BU154329 BU193165 CR536533 CAG38770 DA552678 DA582789 DA699672 DA702185 DA838987 L25610 AAA16109 L26165 AAA19811 L47232 AAB59559 L47233 AAB59560 S67388 AAB29246 U03106 AAC04313 U09579 AAA85641 NM_000389 NP_000380 NM_001220777 NP_001207706 NM_001220778 NP_001207707 NM_001291549 NP_001278478 NM_078467 NP_510867 |
| Function | May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:8242751, ECO:0000269|PubMed:9106657}. |
| Subcellular Location | Cytoplasm. Nucleus. |
| Tissue Specificity | Expressed in all adult tissues, with 5-fold lower levels observed in the brain. |
| Top Pathways | HTLV-I infection, MicroRNAs in cancer, Epstein-Barr virus infection, Oxytocin signaling pathway, Proteoglycans in cancer |