| Gene Symbol | Chst3 |
|---|---|
| Entrez Gene | 53374 |
| Alt Symbol | C6ST, C6ST-1, GST-0 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | carbohydrate (chondroitin 6/keratan) sulfotransferase 3 |
| Other Description | carbohydrate sulfotransferase 3|chondroitin 6-O-sulfotransferase 1|chondroitin 6-sulfotransferase|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0 |
| Swissprots | Q794I5 O88199 |
| Accessions | BAB72166 EDL32179 EDL32180 O88199 AB008937 BAA29054 AB008938 BAA29055 AK134391 BC055055 AAH55055 BP757294 CJ142827 XM_011243510 XP_011241812 XM_011243511 XP_011241813 XM_011243512 XP_011241814 XM_011243513 XP_011241815 NM_016803 NP_058083 |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N- acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen. {ECO:0000269|PubMed:11696535, ECO:0000269|PubMed:9597547}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Widely expressed. Highly expressed in spleen, lung, eye and stomach. Constitutively expressed at low level during the mid- to late-gestation period. Expressed in the brain in a temporally controlled manner: peaks at 2 weeks after birth in the cerebellum, but at 3 weeks in the cerebrum. Localizes to stromal cells in the bone marrow, and stromal cells in the marginal zone and red pulp of the spleen, but the sense probe did not. {ECO:0000269|PubMed:9597547}. |
| Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |