| Gene Symbol | BTRC |
|---|---|
| Entrez Gene | 8945 |
| Alt Symbol | BETA-TRCP, FBW1A, FBXW1, FBXW1A, FWD1, bTrCP, bTrCP1, betaTrCP |
| Species | Human |
| Gene Type | protein-coding |
| Description | beta-transducin repeat containing E3 ubiquitin protein ligase |
| Other Description | E3RSIkappaB|F-box and WD repeats protein beta-TrCP|F-box and WD-repeat protein 1B|F-box/WD repeat-containing protein 1A|beta-TrCP1|epididymis tissue protein Li 2a|pIkappaBalpha-E3 receptor subunit |
| Swissprots | Q9Y213 B5MD49 Q5W142 Q9Y297 Q5W141 |
| Accessions | EAW49770 EAW49771 EAW49772 EAW49773 EAW49774 Q9Y297 AA824369 AF101784 AAD08702 AF129530 AAF04464 AK295870 BAH12210 AK313353 BAG36155 AK313417 BAG36210 AK314880 BAG37395 AL707686 AY207475 AAO59171 AY207476 AAO59172 BC006204 BC027994 AAH27994 BC063673 BM680713 BQ188694 BX389753 CR749295 CAH18150 DA218668 GU727631 ADU87633 JF432214 ADZ15431 Y14153 CAA74572 XM_005270264 XP_005270321 XM_006718054 XP_006718117 XM_011540320 XP_011538622 XR_428727 NM_001256856 NP_001243785 NM_003939 NP_003930 NM_033637 NP_378663 |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys- 21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required fo |
| Subcellular Location | Cytoplasm. Nucleus {ECO:0000250}. |
| Tissue Specificity | Expressed in epididymis (at protein level). {ECO:0000269|PubMed:20736409}. |
| Top Pathways | Wnt signaling pathway, Ubiquitin mediated proteolysis, Hedgehog signaling pathway, Circadian rhythm, Oocyte meiosis |