| Gene Symbol | ID3 |
|---|---|
| Entrez Gene | 3399 |
| Alt Symbol | HEIR-1, bHLHb25 |
| Species | Human |
| Gene Type | protein-coding |
| Description | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
| Other Description | DNA-binding protein inhibitor ID-3|ID-like protein inhibitor HLH 1R21|class B basic helix-loop-helix protein 25|helix-loop-helix protein HEIR-1|inhibitor of differentiation 3 |
| Swissprots | Q02535 O75641 A8K1T8 |
| Accessions | CAA51827 EAW95060 EAW95061 Q02535 A17546 CAA01342 A17548 CAA01343 AK225965 AK290003 BAF82692 BC003107 AAH03107 BM921819 BP193075 BT006791 AAP35437 D28449 BAA05815 DQ892504 ABM83430 DQ895539 ABM86465 DQ895717 ABM86643 X66924 CAA47360 X69111 CAA48862 NM_002167 NP_002158 |
| Function | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. {ECO:0000269|PubMed:8437843}. |
| Subcellular Location | Nucleus. |
| Tissue Specificity | Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain. |
| Top Pathways | TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells |