Gene Symbol |
Acvr2a
|
Entrez Gene |
11480
|
Alt Symbol |
ActrIIa, Acvr2, TactrII
|
Species |
Mouse
|
Gene Type |
protein-coding
|
Description |
activin receptor IIA
|
Other Description |
ACTR-IIA|activin receptor type IIA|activin receptor type-2A
|
Swissprots |
P27038
|
Accessions |
EDL26870 P27038 AK041246 BAC30877 AK050252 BAC34148 AK081022 AK141435 AK143186 AK164527 BC138823 AAI38824 BG066107 BY014959 CK340532 M65287 AAA37171 XM_006497623 XP_006497686 NM_007396 NP_031422
|
Function |
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
|
Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
Tissue Specificity |
Brain, testis, intestine, liver and kidney.
|
Top Pathways |
Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells
|