| Gene Symbol | Brca2 |
|---|---|
| Entrez Gene | 12190 |
| Alt Symbol | Fancd1, RAB163 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | breast cancer 2 |
| Other Description | breast cancer type 2 susceptibility protein homolog|fanconi anemia group D1 protein homolog |
| Swissprots | P97383 O35922 P97929 F8VPU5 |
| Accessions | AAC53276 AAK57537 EDL05880 P97929 AK087379 AK132864 AK145017 AK148272 AK164598 AK165522 BAE38236 BC059904 AAH59904 BC172649 AAI72649 BU755677 U65594 AAC23702 U72947 AAB40720 U82270 AAB48306 U89652 AAB71377 XM_006504906 XP_006504969 XM_006504907 XP_006504970 XM_011241019 XP_011239321 XM_011241020 XP_011239322 XR_377265 NM_001081001 NP_001074470 NM_009765 NP_033895 |
| Function | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) s |
| Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}. |
| Tissue Specificity | Widely expressed. Highest expression in cerebellum, testis, ileum, appendix, epididymis, ovary and mammary gland. No expression in lung. |
| Top Pathways | Homologous recombination, Pancreatic cancer, Fanconi anemia pathway |