| Gene Symbol | OGT |
|---|---|
| Entrez Gene | 8473 |
| Alt Symbol | HRNT1, O-GLCNAC |
| Species | Human |
| Gene Type | protein-coding |
| Description | O-linked N-acetylglucosamine (GlcNAc) transferase |
| Other Description | O-GlcNAc transferase p110 subunit|O-GlcNAc transferase subunit p110|O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)|O-linked N-acetylglucosamine transferase 110 kDa subunit|UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit|UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase|uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase |
| Swissprots | Q8WWM8 O15294 Q96CC1 Q7Z3K0 Q9UG57 |
| Accessions | CAC86127 CAC86128 CAC86129 EAX05285 EAX05286 EAX05287 O15294 AF070560 AF147394 AF223393 AAF31458 AK300267 BAG62028 AK313530 AL049950 AL050366 CAB62528 AL833085 CAD89970 BC014434 AAH14434 BC015144 BC038180 AAH38180 BX537844 CAD97853 CB857907 DA460761 DQ893623 ABM84549 DQ896848 ABM87847 U77413 AAB63466 XM_005262308 XP_005262365 NM_181672 NP_858058 NM_181673 NP_858059 NM_003605 |
| Function | Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta- linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling. Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (PubMed:22923583). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in chromatin s |
| Subcellular Location | Isoform 4: Cytoplasm. Nucleus. |
| Tissue Specificity | Highly expressed in pancreas and to a lesser extent in skeletal muscle, heart, brain and placenta. Present in trace amounts in lung and liver. {ECO:0000269|PubMed:9083068}. |
| Top Pathways | Other types of O-glycan biosynthesis |