UCK2

Gene Symbol UCK2
Entrez Gene 7371
Alt Symbol TSA903, UK, UMPK
Species Human
Gene Type protein-coding
Description uridine-cytidine kinase 2
Other Description cytidine monophosphokinase 2|testis-specific protein TSA903|uridine kinase|uridine monophosphate kinase|uridine monophosphokinase 2
Swissprots Q9BU42 Q5VV91 Q96KG5 Q7KZV3 Q92528 Q9BZX2
Accessions CBN61306 CBN62649 CBN69656 EAW90767 EAW90768 EAW90769 Q9BZX2 AB062451 BAB56162 AF236637 AAK14053 AK294537 BAG57744 AK309739 BC002906 AAH02906 BM714864 BT006860 AAP35506 CR456857 CAG33138 D78335 BAA11349 DR762696 XM_011509969 XP_011508271 XM_011509970 XP_011508272 NM_012474 NP_036606
Function Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine.
Tissue Specificity According to PubMed:8812458; testis-specific. According to PubMed:11306702, placenta-specific. {ECO:0000269|PubMed:8812458}.
Top Pathways Drug metabolism - other enzymes, Pyrimidine metabolism