Dntt

Gene Symbol Dntt
Entrez Gene 21673
Alt Symbol Tdt
Species Mouse
Gene Type protein-coding
Description deoxynucleotidyltransferase, terminal
Other Description DNA nucleotidylexotransferase|terminal addition enzyme|terminal deoxynucleotidyl transferase
Swissprots Q99PD1 P09838 Q99PD0
Accessions AAK01196 EDL41849 P09838 AF316014 AAK07884 AF316015 AAK07885 AK039804 AK087978 BAC40071 AK088709 BAC40518 AK134009 BAE21978 BC027634 BC148334 AAI48335 BX639078 M26145 AAA74592 M26149 X04123 CAA27735 X68670 CAA48634 NM_001043228 NP_001036693 NM_009345 NP_033371
Function Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
Subcellular Location Isoform TDT-S: Nucleus.
Top Pathways Hematopoietic cell lineage, Non-homologous end-joining