| Gene Symbol | AP2A2 |
|---|---|
| Entrez Gene | 161 |
| Alt Symbol | ADTAB, CLAPA2, HIP-9, HIP9, HYPJ |
| Species | Human |
| Gene Type | protein-coding |
| Description | adaptor-related protein complex 2, alpha 2 subunit |
| Other Description | 100 kDa coated vesicle protein C|AP-2 complex subunit alpha-2|adapter-related protein complex 2 subunit alpha-2|adaptin, alpha B|adaptor-related protein complex 2 subunit alpha-2|alpha-adaptin C; Huntingtin interacting protein J|alpha2-adaptin|clathrin assembly protein complex 2 alpha-C large chain|clathrin-associated/assembly/adaptor protein, large, alpha 2|huntingtin yeast partner J|huntingtin-interacting protein 9|plasma membrane adaptor HA2/AP2 adaptin alpha C subunit |
| Swissprots | O75403 Q96SI8 O94973 Q53ET1 |
| Accessions | EAX02416 EAX02417 EAX02418 EAX02419 O94973 AB020706 BAA74922 AB209422 BAD92659 AF049527 AAC27505 AK001986 BAG50999 AK027640 AK027891 BAB55435 AK075497 BAC11653 AK094496 AK095725 AK223558 BAD97278 AK293763 BAH11590 AK299364 BAH13015 AL117614 CAB56015 BC006155 AAH06155 BG705558 BI462785 BU735076 DB461570 DQ893441 ABM84367 DQ896779 ABM87778 XM_011519928 XP_011518230 XM_011519929 XP_011518231 XM_011519930 XP_011518232 XR_930847 NM_001242837 NP_001229766 NM_012305 NP_036437 |
| Function | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to p |
| Subcellular Location | Cell membrane {ECO:0000250}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250}. |
| Top Pathways | Huntington's disease, Endocytosis, Endocrine and other factor-regulated calcium reabsorption, Synaptic vesicle cycle |