| Gene Symbol | ATP6V0E2 |
|---|---|
| Entrez Gene | 155066 |
| Alt Symbol | ATP6V0E2L, C7orf32 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATPase, H+ transporting V0 subunit e2 |
| Other Description | H+-ATPase e2 subunit|V-ATPase subunit e 2|V-type proton ATPase subunit e 2|lysosomal 9 kDa H(+)-transporting ATPase V0 subunit e2|vacuolar proton pump subunit e 2|vacuolar proton-ATPase subunit |
| Swissprots | Q7Z4R7 Q6MZW1 Q8N7I8 A2T8L7 A2T863 J3KQW7 B5MDP5 Q8NHE4 Q75L47 |
| Accessions | AAQ96859 EAW80020 EAW80021 EAW80022 EAW80023 Q8NHE4 AA912295 AF452639 AAP97693 AK057700 AK094602 AK098362 BAC05292 AK172725 AK290086 BAF82775 AY037164 AAK67647 BC015899 BE677432 BX640846 CAE45916 DB544557 DQ989009 ABK88279 DQ995344 ABK76305 NM_001100592 NP_001094062 NM_001289990 NP_001276919 NM_145230 NP_660265 NR_110612 |
| Function | Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. {ECO:0000250}. |
| Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Tissue Specificity | Isoform 1 is expressed at high levels in heart, brain and kidney and also detected in inner ear epithelium, vestibule, testis, epididymis and bladder. Isoform 2 is expressed in heart, kidney, placenta and pancreas. Isoform 2 is not detected in frontal cortex, but is prevalent in all other brain areas. {ECO:0000269|PubMed:17350184}. |
| Top Pathways | Epithelial cell signaling in Helicobacter pylori infection, Vibrio cholerae infection, Collecting duct acid secretion, Phagosome, Rheumatoid arthritis |