| Gene Symbol | GLYAT |
|---|---|
| Entrez Gene | 10249 |
| Alt Symbol | ACGNAT, CAT, GAT |
| Species | Human |
| Gene Type | protein-coding |
| Description | glycine-N-acyltransferase |
| Other Description | AAc|HRP-1(CLP)|acyl-CoA:glycine N-acyltransferase|aralkyl acyl-CoA N-acyltransferase|aralkyl acyl-CoA:amino acid N-acyltransferase|aralkyl-CoA N-acyltransferase|benzoyl-coenzyme A:glycine N-acyltransferase|glycine N-acyltransferase|glycine N-benzoyltransferase |
| Swissprots | Q96QK7 Q6IB77 O14833 |
| Accessions | EAW73822 EAW73823 EAW73824 Q6IB77 AB013093 AB665285 BAL43174 AF023466 AAB81453 AI253073 AI793012 AI793201 AW024233 BC009785 AAH09785 BG401676 BG617408 BP277146 CB161978 CR456927 CAG33208 DQ892712 ABM83638 DQ895964 ABM86890 DR004166 NM_005838 NP_005829 NM_201648 NP_964011 |
| Function | Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. {ECO:0000269|PubMed:22475485, ECO:0000269|PubMed:7802672}. |
| Subcellular Location | Mitochondrion {ECO:0000269|PubMed:22475485}. |
| Tissue Specificity | Predominantly expressed in liver (at protein level) and kidney. Down-regulated in hepatocellular carcinoma and other liver cancers. {ECO:0000269|PubMed:22475485}. |
| Top Pathways | Phenylalanine metabolism |