| Gene Symbol | REN |
|---|---|
| Entrez Gene | 5972 |
| Alt Symbol | HNFJ2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | renin |
| Other Description | angiotensin-forming enzyme|angiotensinogenase|renin precursor, renal |
| Swissprots | Q6FI38 P00797 Q6T5C2 |
| Accessions | AAA60262 AAA60263 AAA60363 AAA60364 AAA60365 AAD03461 AAR03502 ABY87560 EAW91505 P00797 AF117822 AAD26254 BC033474 AAH33474 BC047752 AAH47752 BP321283 CR536498 CAG38737 HQ448652 ADQ33130 X00063 CAA24937 NM_000537 NP_000528 |
| Function | Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. |
| Subcellular Location | Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2. |
| Top Pathways | Renin-angiotensin system |