Hyal2

Gene Symbol Hyal2
Entrez Gene 15587
Alt Symbol AI256841, AU020858, AW555733
Species Mouse
Gene Type protein-coding
Description hyaluronoglucosaminidase 2
Other Description hyal-2|hyaluronidase 2|hyaluronidase-2|hyaluronoglucosaminidase-2
Swissprots Q99MT0 Q99MS9 O35631 O35632
Accessions CAA03889 EDL21201 EDL21202 O35632 AF302843 AAK28481 AF302844 AAK28482 AF422177 AAL17823 AF535140 AAO49503 AJ000059 CAA03888 AK080146 AK087358 BAC39851 AK088806 BAC40583 AK133886 BAE21913 BC060047 XM_006511643 XP_006511706 XM_006511644 XP_006511707 XM_006511645 XP_006511708 NM_010489 NP_034619
Function Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Tissue Specificity Widely expressed. In the brain, expressed during embryonic stages but expression decreases after birth and is barely detectable in adult brain. {ECO:0000269|PubMed:9790770}.
Top Pathways Glycosaminoglycan degradation