INPP5B

Gene Symbol INPP5B
Entrez Gene 3633
Alt Symbol 5PTase
Species Human
Gene Type protein-coding
Description inositol polyphosphate-5-phosphatase, 75kDa
Other Description phosphoinositide 5-phosphatase|type II inositol 1,4,5-trisphosphate 5-phosphatase
Swissprots Q658Q5 C9J6U5 P32019 Q5VSH0 Q6P6D4 Q6PD53 Q86YE1 Q5VSH1 Q5VSG9
Accessions EAX07307 EAX07308 EAX07309 EAX07310 EAX07311 P32019 AK022846 BAG51126 AK093261 AK295062 BAG58111 AK310824 AL833055 CAH56301 BC042529 AAH42529 BC058932 AAH58932 BC062317 DA125087 DC398675 M74161 AAA79207 XM_005270835 XP_005270892 XM_006710619 XP_006710682 XM_006710621 XP_006710684 XM_011541387 XP_011539689 XM_011541388 XP_011539690 XM_011541389 XP_011539691 XM_011541390 XP_011539692 XM_011541391 XP_011539693 XM_011541392 XP_011539694 XM_011541393 XP_011539695 XR_946643 XR_946644 NM_001297434 NP_001284363 NM_005540 NP_005531
Function Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. {ECO:0000269|PubMed:7721860}.
Subcellular Location Cytoplasm, cytosol. Endoplasmic reticulum- Golgi intermediate compartment. Early endosome membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Golgi apparatus.
Tissue Specificity Platelets.
Top Pathways Inositol phosphate metabolism, Phosphatidylinositol signaling system