| Gene Symbol | POLR1C |
|---|---|
| Entrez Gene | 9533 |
| Alt Symbol | RPA39, RPA40, RPA5, RPAC1, TCS3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | polymerase (RNA) I polypeptide C, 30kDa |
| Other Description | AC40|DNA-directed RNA polymerase I subunit C|DNA-directed RNA polymerases I and III 40 kDa polypeptide|DNA-directed RNA polymerases I and III subunit RPAC1|RNA polymerases I and III subunit AC1|RPC40 |
| Swissprots | O15160 Q5JTE3 O75395 |
| Accessions | CCQ43287 EAX04204 EAX04205 EAX04208 O15160 AF008442 AAC14354 AF047441 AAC39892 AK293561 BAG57033 BC008118 AAH08118 BC008863 AAH08863 BM828768 BQ575535 HQ448228 ADQ32708 XM_005249491 XP_005249548 XM_011515000 XP_011513302 NM_203290 NP_976035 NM_004875 |
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000250}. |
| Top Pathways | Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism |