ACOT2

Gene Symbol ACOT2
Entrez Gene 10965
Alt Symbol CTE-IA, CTE1A, MTE1, PTE2, PTE2A, ZAP128
Species Human
Gene Type protein-coding
Description acyl-CoA thioesterase 2
Other Description acyl-coenzyme A thioester hydrolase 2a|acyl-coenzyme A thioesterase 2, mitochondrial|long-chain acyl-CoA thioesterase 2|mitochondrial acyl-CoA thioesterase 1|peroxisomal long-chain acyl-coA thioesterase 2
Swissprots Q3I5F8 P49753 Q9NUX4 Q53EK4
Accessions P49753 AI537078 AK001939 BAA91989 AK093131 BAG52662 AK223635 BAD97355 AY005822 AAF97985 BC004436 AAH04436 BC006335 AAH06335 BC006500 AAH06500 DQ082755 AAZ31237 DQ893488 ABM84414 DQ896406 ABM87405 L40401 AAC42007 XM_006720007 XP_006720070 NM_006821 NP_006812 NR_046028
Function Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs. {ECO:0000269|PubMed:10944470}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:16940157}.
Tissue Specificity Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas. {ECO:0000269|PubMed:16940157}.
Top Pathways Ovarian steroidogenesis, Fatty acid elongation, Biosynthesis of unsaturated fatty acids