| Gene Symbol | SLC2A2 |
|---|---|
| Entrez Gene | 6514 |
| Alt Symbol | GLUT2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | solute carrier family 2 (facilitated glucose transporter), member 2 |
| Other Description | glucose transporter type 2, liver|solute carrier family 2, facilitated glucose transporter member 2 |
| Swissprots | F8W8V8 B2R936 P11168 Q9UCW9 A8K481 B7Z547 |
| Accessions | CBN59495 CBN65426 EAW78498 EAW78499 EAW78500 P11168 AK290846 BAF83535 AK292741 BAF85430 AK298418 BAH12783 AK313622 BAG36383 BC060041 AAH60041 J03810 AAA59514 XM_011513087 XP_011511389 XM_011513088 XP_011511390 XM_011513089 XP_011511391 NM_000340 NP_000331 NM_001278658 NP_001265587 NM_001278659 NP_001265588 |
| Function | Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Liver, insulin-producing beta cell, small intestine and kidney. |
| Top Pathways | Type II diabetes mellitus, Maturity onset diabetes of the young, Carbohydrate digestion and absorption, Prolactin signaling pathway, Central carbon metabolism in cancer |