| Gene Symbol | PLA2G1B |
|---|---|
| Entrez Gene | 5319 |
| Alt Symbol | PLA2, PLA2A, PPLA2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | phospholipase A2, group IB (pancreas) |
| Other Description | phosphatidylcholine 2-acylhydrolase 1B|phospholipase A2 |
| Swissprots | B2R4H5 Q3KPI1 P04054 |
| Accessions | AAA60107 AAB95635 AAR05441 EAW98184 P04054 AA844927 AK311830 BAG34772 BC005386 AAH05386 BC013384 BC106725 AAI06726 BC106726 AAI06727 BE969737 BX113838 CA867923 EU832774 ACE87785 GQ129318 ACT64452 M21054 AAA36450 NM_000928 NP_000919 |
| Function | PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. {ECO:0000269|PubMed:19297324}. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:19297324}. Note=secreted from pancreatic acinar cells in its inactive form. |
| Top Pathways | Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism |