| Gene Symbol | Aadat |
|---|---|
| Entrez Gene | 23923 |
| Alt Symbol | AI875679, Aadt, KATII, Kat2, mKat-2 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | aminoadipate aminotransferase |
| Other Description | 2-aminoadipate aminotransferase|2-aminoadipate transaminase|KAT/AadAT|alpha-aminoadipate aminotransferase|kynurenine aminotransferase II|kynurenine--oxoglutarate aminotransferase II|kynurenine--oxoglutarate transaminase 2|kynurenine--oxoglutarate transaminase II|kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
| Swissprots | Q9WVM8 |
| Accessions | EDL28634 Q9WVM8 AF072376 AAD39680 AK075578 BAC35833 AK144042 BAE25669 BC012637 AAH12637 XM_006509397 XP_006509460 XM_011242215 XP_011240517 NM_011834 NP_035964 |
| Function | Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) (By similarity). {ECO:0000250}. |
| Subcellular Location | Mitochondrion {ECO:0000305}. |
| Tissue Specificity | Expressed mainly in kidney and to a lesser amount in liver and brain. {ECO:0000269|PubMed:10441733}. |
| Top Pathways | Lysine degradation, Tryptophan metabolism, Lysine biosynthesis, Biosynthesis of amino acids, 2-Oxocarboxylic acid metabolism |