| Gene Symbol | PTPRZ1 |
|---|---|
| Entrez Gene | 5803 |
| Alt Symbol | HPTPZ, HPTPzeta, PTP-ZETA, PTP18, PTPRZ, PTPZ, R-PTP-zeta-2, RPTPB, RPTPbeta, phosphacan |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 |
| Other Description | protein tyrosine phosphatase, receptor-type, zeta polypeptide 1|protein-tyrosine phosphatase receptor type Z polypeptide 2|receptor-type tyrosine phosphatase beta/zeta|receptor-type tyrosine-protein phosphatase zeta |
| Swissprots | Q9UDR6 C9JFM0 P23471 O76043 A4D0W5 |
| Accessions | AAF03527 EAL24344 EAW83560 EAW83561 EAW83562 EAW83563 P23471 AK294062 BAG57408 BC131736 BC172407 AAI72407 CX868991 CX872418 DA101746 DA454064 M93426 AAA60225 U88967 AAC39934 X54135 CAA38070 XM_005250519 XP_005250576 XR_927505 NM_001206838 NP_001193767 NM_001206839 NP_001193768 NM_002851 NP_002842 |
| Function | Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity). {ECO:0000250}. |
| Subcellular Location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Secreted {ECO:0000250}. Note=A secreted form is apparently generated by shedding of the extracellular domain. {ECO:0000250}. |
| Tissue Specificity | Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain. {ECO:0000269|PubMed:9653645}. |
| Top Pathways | Epithelial cell signaling in Helicobacter pylori infection |