| Gene Symbol | Gls |
|---|---|
| Entrez Gene | 14660 |
| Alt Symbol | 6330442B14, AI314027, B230365M23Rik |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | glutaminase |
| Other Description | glutaminase kidney isoform, mitochondrial |
| Swissprots | D3Z7P3 Q69ZX9 E9PUF0 |
| Accessions | D3Z7P3 AK031899 AK032267 AK046297 AK048072 AK049883 AK079838 AK088231 AK141044 AK173039 BAD32317 BC025534 BC050208 BC169203 BE849049 XM_006495701 XP_006495764 XM_006495702 XP_006495765 XM_006495703 XP_006495766 XM_006495704 XP_006495767 XR_373241 NM_001081081 NP_001074550 NM_001113383 NP_001106854 |
| Function | Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. {ECO:0000269|PubMed:16641247, ECO:0000269|PubMed:22228304, ECO:0000269|PubMed:22373647}. |
| Subcellular Location | Isoform 1: Cytoplasm, cytosol {ECO:0000250}. |
| Top Pathways | Central carbon metabolism in cancer, MicroRNAs in cancer, Glutamatergic synapse, GABAergic synapse, Proximal tubule bicarbonate reclamation |