DPM2

Gene Symbol DPM2
Entrez Gene 8818
Alt Symbol CDG1U
Species Human
Gene Type protein-coding
Description dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
Other Description DPM synthase complex subunit|DPM synthase subunit 2|dolichol phosphate-mannose biosynthesis regulatory protein|dolichol-phosphate mannose synthase subunit 2
Swissprots O94777 Q6FGH3 Q5XKK9
Accessions O94777 AB013361 BAA33974 AB451329 BAG70143 AB451473 BAG70287 AF061729 AAG43140 AI954002 AK312121 BAG35057 BC015233 AAH15233 BC015374 AAH15374 BC048256 BC107863 AAI07864 CR542134 CAG46931 NM_003863 NP_003854 NM_152690
Function Regulates the biosynthesis of dolichol phosphate- mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity. {ECO:0000269|PubMed:10944123}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Top Pathways N-Glycan biosynthesis, Glycosylphosphatidylinositol(GPI)-anchor biosynthesis