| Gene Symbol | PLOD2 |
|---|---|
| Entrez Gene | 5352 |
| Alt Symbol | BRKS2, LH2, TLH |
| Species | Human |
| Gene Type | protein-coding |
| Description | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 |
| Other Description | lysine hydroxylase 2|lysyl hydroxlase 2|lysyl hydroxylase 2|procollagen-lysine,2-oxoglutarate 5-dioxygenase 2|telopeptide lysyl hydroxylase |
| Swissprots | O00469 B3KWS3 Q8N170 Q59ED2 |
| Accessions | AAD40977 AAK20119 EAW78939 EAW78940 EAW78941 O00469 AB209879 BAD93116 AK125700 BAG54235 AK130098 AK295084 BAG58125 AL832238 BC016834 AAH16834 BC037169 AAH37169 BM724669 BX537521 U84573 AAB58363 XM_005247535 XP_005247592 XM_005247536 XP_005247593 NM_000935 NP_000926 NM_182943 NP_891988 |
| Function | Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. |
| Subcellular Location | Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. |
| Tissue Specificity | Highly expressed in pancreas and muscle. Isoform 1 and isoform 2 are expressed in the majority of the examined cell types. Isoform 2 is specifically expressed in skin, lung, dura and aorta. {ECO:0000269|PubMed:10372558}. |
| Top Pathways | Lysine degradation |