| Gene Symbol | AP2B1 |
|---|---|
| Entrez Gene | 163 |
| Alt Symbol | ADTB2, AP105B, AP2-BETA, CLAPB1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | adaptor-related protein complex 2, beta 1 subunit |
| Other Description | AP-2 complex subunit beta|adapter-related protein complex 2 beta subunit|adapter-related protein complex 2 subunit beta|adaptin, beta 2 (beta)|adaptor protein complex AP-2 subunit beta|adaptor-related protein complex 2 subunit beta|beta-2-adaptin|beta-adaptin|clathrin assembly protein complex 2 beta large chain|clathrin-associated/assembly/adaptor protein, large, beta 1|plasma membrane adaptor HA2/AP2 adaptin beta subunit |
| Swissprots | P63010 Q7Z451 A6NJP3 Q96J19 |
| Accessions | EAW80133 EAW80134 EAW80135 EAW80136 EAW80137 EAW80138 EAW80139 EAW80140 EAW80141 EAW80142 P63010 AI691147 AK289528 BAF82217 AK292531 BAF85220 AK295667 BAG58527 AK301522 BAG63026 AK304126 BAG65023 AY341427 AAQ20044 BC006201 AAH06201 BC012150 AAH12150 BQ421703 BX643620 CR749392 CAH18240 DQ893282 ABM84208 DQ896613 ABM87612 M34175 AAA35583 XM_005257937 XP_005257994 XM_005257938 XP_005257995 XM_005257941 XP_005257998 XM_011524448 XP_011522750 XM_011524449 XP_011522751 XM_011524450 XP_011522752 XM_011524451 XP_011522753 XM_011524452 XP_011522754 XM_011524453 XP_011522755 XM_011524454 XP_011522756 XM_011524455 XP_011522757 NM_001030006 NP_001025177 NM_001282 NP_001273 |
| Function | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to p |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:14530274}. Membrane, coated pit {ECO:0000269|PubMed:14530274}; Peripheral membrane protein {ECO:0000269|PubMed:14530274}; Cytoplasmic side {ECO:0000269|PubMed:14530274}. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. |
| Top Pathways | Huntington's disease, Endocytosis, Endocrine and other factor-regulated calcium reabsorption, Synaptic vesicle cycle |