| Gene Symbol | CR1 |
|---|---|
| Entrez Gene | 1378 |
| Alt Symbol | C3BR, C4BR, CD35, KN |
| Species | Human |
| Gene Type | protein-coding |
| Description | complement component (3b/4b) receptor 1 (Knops blood group) |
| Other Description | C3-binding protein|C3b/C4b receptor|CD35 antigen|Knops blood group antigen|complement receptor type 1 |
| Swissprots | Q5SR45 Q16744 Q16745 P17927 Q5SR43 Q9UQV2 |
| Accessions | AAB60694 AAB60695 AAD15289 AAG09139 AAG09140 AAG14442 AAG14443 AAV65566 AAV65567 AAV65568 AAV65569 AAV65570 AAV65571 AAV65572 AAV65573 AAV65574 AAV65575 AAV65576 AAV65577 CAA32538 CAA32540 CAE82047 CDK60404 EAW93480 P17927 AK298486 BAG60695 AK309342 BC032550 BF900429 BX113709 BX643705 M11569 AAA52297 M11617 AAA52298 M11618 AAA52299 X05309 CAA28933 X14362 CAA32541 Y00816 CAA68755 XM_006711166 XP_006711229 XM_011509205 XP_011507507 NM_000573 NP_000564 NM_000651 NP_000642 |
| Function | Mediates cellular binding of particles and immune complexes that have activated complement. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. |
| Top Pathways | Complement and coagulation cascades, Hematopoietic cell lineage, Leishmaniasis, Malaria, Tuberculosis |