| Gene Symbol |
YWHAB
|
| Entrez Gene |
286863
|
| Alt Symbol |
-
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
|
| Other Description |
14-3-3 protein beta/alpha|KCIP-1|protein kinase C inhibitor protein 1|tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
|
| Swissprots |
Q0VCL1 P68250 P29358
|
| Accessions |
DAA23130 P68250 AF043736 AAC02090 BC120112 AAI20113 NM_174794 NP_777219
|
| Function |
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Melanosome {ECO:0000250}.
|
| Top Pathways |
Cell cycle, Oocyte meiosis, Viral carcinogenesis, PI3K-Akt signaling pathway, Epstein-Barr virus infection
|
![Anti-14-3-3 antibody [E58] (ab32377) at 1/1000 dilution + Hela cell lysate.](http://www.bioprodhub.com/system/product_images/ab_products/2/sub_1/101_ab32377_1.jpg)