Pla2g5

Gene Symbol Pla2g5
Entrez Gene 18784
Alt Symbol PLA2, sPLA2
Species Mouse
Gene Type protein-coding
Description phospholipase A2, group V
Other Description PLA2-10|calcium-dependent phospholipase A2|group V phospholipase A2|phosphatidylcholine 2-acylhydrolase 5
Swissprots P97391 Q9QZU6
Accessions EDL13279 EDL13280 EDL13281 EDL13282 P97391 AF162713 AAD45807 AK090021 BAC41050 AK157266 BAE34019 AK161336 BAE36332 BC030899 AAH30899 BY012884 BY015217 CK384107 U66873 AAC53038 XM_006538658 XP_006538721 XM_011250208 XP_011248510 NM_001122954 NP_001116426 NM_011110 NP_035240
Function PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes L- alpha-palmitoyl-2-oleoyl phosphatidylcholine more efficiently than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1- palmitoyl-2-arachidonyl phosphatidylethanolamine or L-alpha-1- stearoyl-2-arachidonyl phosphatidylinositol (By similarity). {ECO:0000250}.
Subcellular Location Secreted {ECO:0000269|PubMed:10531350}. Membrane {ECO:0000269|PubMed:10531350}. Note=Also associated with various membranous organelles including the Golgi apparatus, nuclear envelope, and plasma membrane.
Top Pathways Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism