Ggt5

Gene Symbol Ggt5
Entrez Gene 29566
Alt Symbol Ggta1, Ggtla1
Species Rat
Gene Type protein-coding
Description gamma-glutamyltransferase 5
Other Description GGL|GGT 5|GGT-rel|gamma-glutamyl leukotrienase|gamma-glutamyl transpeptidase-related enzyme|gamma-glutamyltransferase-like activity 1|gamma-glutamyltranspeptidase 5|glutathione hydrolase 5|leukotriene-C4 hydrolase
Swissprots Q9QWE9
Accessions EDL97198 Q9QWE9 BC087018 AAH87018 U76252 AAC23546 NM_019235 NP_062108
Function Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).
Subcellular Location Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue Specificity Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.
Top Pathways Taurine and hypotaurine metabolism, Glutathione metabolism, Arachidonic acid metabolism, Cyanoamino acid metabolism