| Gene Symbol | CAMK2D |
|---|---|
| Entrez Gene | 817 |
| Alt Symbol | CAMKD |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcium/calmodulin-dependent protein kinase II delta |
| Other Description | CaM kinase II delta subunit|CaM-kinase II delta chain|CaMK-II delta subunit|caM kinase II subunit delta|caMK-II subunit delta|calcium/calmodulin-dependent protein kinase (CaM kinase) II delta|calcium/calmodulin-dependent protein kinase type II delta chain|calcium/calmodulin-dependent protein kinase type II subunit delta |
| Swissprots | Q52PK4 Q9UQE9 A8MVS8 Q9UGH6 Q13557 Q8N553 Q59G21 |
| Accessions | EAX06295 EAX06296 EAX06297 EAX06298 EAX06299 EAX06300 EAX06301 Q13557 AB209288 BAD92525 AF071569 AAD20442 AI004608 AI057019 AJ252239 CAB65123 AK025368 AK055642 BAG51545 AK294517 BAH11796 AL120285 AY987011 AAX88806 BC022558 AAH22558 BC032784 AAH32784 BX538071 BX647363 CA416772 CF551834 DA113081 DQ895255 ABM86181 EF139846 EU176241 ABW03692 U50361 AAB16866 U73738 AAB18327 XM_005263251 XP_005263308 XM_005263252 XP_005263309 XM_005263253 XP_005263310 XM_005263254 XP_005263311 XM_005263255 XP_005263312 XM_005263256 XP_005263313 XM_005263257 XP_005263314 XM_005263258 XP_005263315 XM_005263260 XP_005263317 XM_005263261 XP_005263318 XM_006714329 XP_006714392 XM_006714330 XP_006714393 XM_011532289 XP_011530591 XM_011532290 XP_011530592 XM_011532291 XP_011530593 XM_011532292 XP_011530594 XM_011532293 XP_011530595 XM_011532294 XP_011530596 XM_011532295 XP_011530597 XM_011532296 XP_011530598 XR_938774 XR_938775 NM_001221 NP_001212 NM_172114 NP_742112 NM_172115 NP_742113 NM_172127 NP_742125 NM_172128 NP_742126 NM_172129 NP_742127 |
| Function | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser- 2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remo |
| Subcellular Location | Cell membrane, sarcolemma {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Sarcoplasmic reticulum membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. |
| Tissue Specificity | Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle. {ECO:0000269|PubMed:10189359, ECO:0000269|PubMed:16690701}. |
| Top Pathways | Wnt signaling pathway, Glucagon signaling pathway, Adrenergic signaling in cardiomyocytes, cAMP signaling pathway, Inflammatory mediator regulation of TRP channels |