CNGA1

Gene Symbol CNGA1
Entrez Gene 1259
Alt Symbol CNCG, CNCG1, CNG-1, CNG1, RCNC1, RCNCa, RCNCalpha, RP49
Species Human
Gene Type protein-coding
Description cyclic nucleotide gated channel alpha 1
Other Description CNG channel alpha-1|cGMP-gated cation channel alpha-1|cyclic nucleotide-gated cation channel 1|cyclic nucleotide-gated channel alpha-1|cyclic nucleotide-gated channel, photoreceptor|interleukin-1 homologue|rod photoreceptor cGMP-gated channel subunit alpha
Swissprots Q4W5E3 Q16485 Q16279 J3KPZ2 A8K7K6 P29973
Accessions AAD14206 AAY40919 EAW93048 EAW93049 P29973 AK292021 BAF84710 BC140399 AAI40400 M84741 AAA52010 S42457 AAB22778 W89170 W93472 X64802 CAA46027 XM_005248049 XP_005248106 XM_011513623 XP_011511925 NM_000087 NP_000078 NM_001142564 NP_001136036
Function Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Rod cells in the retina.
Top Pathways Phototransduction, cGMP-PKG signaling pathway, cAMP signaling pathway