| Gene Symbol | PC |
|---|---|
| Entrez Gene | 5091 |
| Alt Symbol | PCB |
| Species | Human |
| Gene Type | protein-coding |
| Description | pyruvate carboxylase |
| Other Description | pyruvate carboxylase, mitochondrial|pyruvic carboxylase |
| Swissprots | P11498 B4DN00 Q16705 |
| Accessions | CBF60260 CBF61085 CBF62141 CBF64322 CBF68536 CBF95786 CBU85504 CBU86113 CBU87017 CBU89198 CBU93410 CBV09306 EAW74568 EAW74569 EAW74570 EAW74571 EAW74572 P11498 AK297705 BAG60062 BC011617 AAH11617 CN267865 DA542083 K02282 AAA60033 M26122 AAA36423 S72370 AAB31500 U04641 AAA99537 U30889 U30890 U30891 AAA82937 XM_005274031 XP_005274088 XM_005274032 XP_005274089 XM_006718577 XP_006718640 XM_006718578 XP_006718641 XM_006718579 XP_006718642 XM_011545085 XP_011543387 XM_011545086 XP_011543388 XM_011545087 XP_011543389 XM_011545088 XP_011543390 NM_000920 NP_000911 NM_001040716 NP_001035806 NM_022172 NP_071504 |
| Function | Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. |
| Subcellular Location | Mitochondrion matrix. |
| Top Pathways | Citrate cycle (TCA cycle), Pyruvate metabolism, Biosynthesis of amino acids, Carbon metabolism |