| Gene Symbol | NTRK1 |
|---|---|
| Entrez Gene | 4914 |
| Alt Symbol | MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA |
| Species | Human |
| Gene Type | protein-coding |
| Description | neurotrophic tyrosine kinase, receptor, type 1 |
| Other Description | Oncogene TRK|TRK1-transforming tyrosine kinase protein|gp140trk|high affinity nerve growth factor receptor|tropomyosin-related kinase A|tyrosine kinase receptor A |
| Swissprots | Q7Z5C3 Q5VZS2 P04629 Q5D056 B7ZM34 Q15655 Q9UIU7 P08119 B2R6T5 |
| Accessions | AAP88292 BAA34355 CDI70969 EAW52900 EAW52901 EAW52902 P04629 AK126428 AK290759 BAF83448 AK312704 BAG35582 BC062580 AAH62580 BC136554 AAI36555 BC144239 AAI44240 BM685020 CR936794 KJ534902 AHW56542 KJ534903 AHW56543 M23102 AAA36770 NM_001007792 NP_001007793 NM_001012331 NP_001012331 NM_002529 NP_002520 |
| Function | Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras- PI3 kin |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:15488758}; Single-pass type I membrane protein {ECO:0000269|PubMed:15488758}. Early endosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes (By similarity). {ECO:0000250}. |
| Tissue Specificity | Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. {ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:8325889}. |
| Top Pathways | Central carbon metabolism in cancer, Apoptosis, Inflammatory mediator regulation of TRP channels, Endocytosis, Neurotrophin signaling pathway |