Ccnd1

Gene Symbol	Ccnd1
Entrez Gene	12443
Alt Symbol	AI327039, CycD1, Cyl-1, PRAD1, bcl-1, cD1
Species	Mouse
Gene Type	protein-coding
Description	cyclin D1
Other Description	G1/S-specific cyclin-D1
Swissprots	P25322
Accessions	AAF23491 AAO13813 EDL18282 EDL18283 P25322 AK005352 AK017834 AK053348 BAC35355 AK149905 BAE29157 AK164997 BAE37996 AK169905 AK170833 BAE42061 BC044841 AAH44841 BC060172 BY089102 EU600170 ACC78286 M64403 AAA37502 S78355 AAB34495 XM_011241977 XP_011240279 NM_007631 NP_031657
Function	Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:19767775}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Cyclin D- CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.
Top Pathways	Acute myeloid leukemia, Cell cycle, Prolactin signaling pathway, MicroRNAs in cancer, Bladder cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Cyclin D1 (CCND1), Mouse, ELISA Kit - SEA585Mu from ARP American Research Products Category ELISA Kit Prices $668.00 Sizes 96 t Sensitivity 5.7pg/mL Range 15.6-1,000pg/mL

G1/S-specific cyclin-D1, Ccnd1, Mouse, ELISA Kit - E0585m from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Mouse CCND1 ELISA Kit - MC0490 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Mouse CD1 ELISA Kit - MC0864 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Mouse CCND1(Cyclin D1) ELISA Kit - E-EL-M0381 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Mouse CCND1 (Cyclin-D1) CLIA Kit - E-CL-M0244 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

Cyclin D1 (CCND1), ELISA Kit - MBS2021472 from MyBioSource Category ELISA Kit Prices $350.00, $525.00, $715.00, $2,915.00, $5,315.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.054ng/mL. Range 0.156-10ng/mL

Cyclin D1 (CCND1), ELISA Kit - MBS262917 from MyBioSource Category ELISA Kit Prices $290.00, $450.00, $1,755.00, $3,150.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mouse Cyclin D1 ELISA - E03C0483 from BlueGene Biotech Category ELISA Kit Sensitivity 0.1 ng/mL

ELISA Kit for Cyclin D1 (CCND1) - SEA585Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.054ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Mouse Cyclin D1 (CCND1) ELISA Kit - EKU03532 from Biomatik Category ELISA Kit Prices $680.00, $3,028.00, $5,511.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.054 ng/mL Range 0.156-10 ng/mL

Mouse CCND1(Cyclin D1) ELISA Kit - E-EL-M0381 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mL Range 0.16~10 ng/mL

Mouse CCND1 (Cyclin-D1) CLIA Kit - E-CL-M0244 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 0.094ng/mL Range 0.156-10ng/mL

Mouse Cyclin D1 ELISA Kit - abx153883 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Mouse G1/S-specific cyclin-D1 ELISA Kit - abx254769 from Abbexa Category ELISA Kit Range 0.312 ng/ml - 20 ng/ml

Cyclin D1 (CCND1), Mouse, ELISA Kit - DL-CCND1-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 0.156-10 ng/mL

CCND1 (Cyclin-D1), CLIA Kit - MBS2531368 from MyBioSource Category CLIA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 18.75pg/mL Range 31.25-2000pg/mL

Mouse CCND1 ELISA Kit - orb364864 from Biorbyt Category ELISA Kit Prices $519.00, $587.00 Sizes 48 test, 96 test Range Detection Range: 15.625-1000pg/mL Detection low threshold: 5.7pg/mL

Mouse CCND1 ELISA Kit - abx574401 from Abbexa Category ELISA Kit Sensitivity 5.7 pg/ml Range 15.625 pg/ml - 1000 pg/ml

Mouse G1/S-specific cyclin-D1 ELISA Kit - EKE53058 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Range 0.312-20 ng/mL

CCND1 - EKM0828 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

CCND1 - EKM828 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Mouse Ccnd1 ELISA Kit - E049918 from Biobool Category ELISA Kit

Mouse cyclin D1 ELISA Kit - E049962 from Biobool Category ELISA Kit

CCND1 ELISA Kit (Mouse) (OKEH03154) - OKEH03154 from Aviva Systems Biology Category ELISA Kit Prices $425.00 Sizes 96 wells Sensitivity 0.156 ng/mL Range 0.312 - 20 ng/mL

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