Ccnd1

Gene Symbol	Ccnd1
Entrez Gene	12443
Alt Symbol	AI327039, CycD1, Cyl-1, PRAD1, bcl-1, cD1
Species	Mouse
Gene Type	protein-coding
Description	cyclin D1
Other Description	G1/S-specific cyclin-D1
Swissprots	P25322
Accessions	AAF23491 AAO13813 EDL18282 EDL18283 P25322 AK005352 AK017834 AK053348 BAC35355 AK149905 BAE29157 AK164997 BAE37996 AK169905 AK170833 BAE42061 BC044841 AAH44841 BC060172 BY089102 EU600170 ACC78286 M64403 AAA37502 S78355 AAB34495 XM_011241977 XP_011240279 NM_007631 NP_031657
Function	Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:19767775}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Cyclin D- CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.
Top Pathways	Acute myeloid leukemia, Cell cycle, Prolactin signaling pathway, MicroRNAs in cancer, Bladder cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Mouse Cyclin D1 Protein - abx066194 from Abbexa Category Protein Source E.coli Species Mouse

Cyclin D1 (CCND1), Mouse - 20-6857 from ARP American Research Products Category Protein Prices $549.00 Sizes 50 µg Source E.coli Species Mouse

Recombinant Cyclin D1 (CCND1) - RPA585Mu01 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Cyclin D1 (CCND1) - RPA585Mu02 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Mouse G1/S-specific cyclin-D1(Ccnd1) - CSB-YP004811MO CSB-EP004811MO CSB-BP004811MO CSB-MP004811MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

CD1 (22-297) - sc-4525 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Mouse

Cyclin D1 (CCND1) - RPU141066 from Biomatik Category Protein Prices $264.00, $528.00, $792.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Mouse

Recombinant Mouse CCND1 Protein - CCND1-2988M from Creative Biomart Category Protein Source Mammalian Cells Species Mouse

G1/S-specific cyclin-D1 (Ccnd1), Recombinant Protein - MBS959437 from MyBioSource Category Protein Prices $1,050.00, $1,050.00, $1,280.00, $1,280.00, $1,635.00, $1,635.00, $2,100.00, $2,100.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Mouse

Recombinant Cyclin D1 (CCND1) - RPU41066 from Biomatik Category Protein Prices $211.00, $413.00, $660.00, $787.20 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Mouse

CCND1 Recombinant Protein (OPCD01972) - OPCD01972 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

Cyclin D1 (CCND1), Recombinant Protein - MBS2012339 from MyBioSource Category Protein Prices $200.00, $430.00, $665.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

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