WNT1

Gene Symbol WNT1
Entrez Gene 7471
Alt Symbol BMND16, INT1, OI15
Species Human
Gene Type protein-coding
Description wingless-type MMTV integration site family, member 1
Other Description proto-oncogene Int-1 homolog|proto-oncogene Wnt-1|wingless-type MMTV integration site family, member 1 (oncogene INT1)
Swissprots Q5U0N2 P04628
Accessions CAA26874 CAI38639 EAW58030 P04628 BC074798 AAH74798 BC074799 AAH74799 BT019429 AAV38236 NM_005430 NP_005421
Function Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development. {ECO:0000269|PubMed:23499309}.
Subcellular Location Secreted, extracellular space, extracellular matrix.
Top Pathways Proteoglycans in cancer, Wnt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Hippo signaling pathway, HTLV-I infection