RHOG

Gene Symbol RHOG
Entrez Gene 391
Alt Symbol ARHG
Species Human
Gene Type protein-coding
Description ras homolog family member G
Other Description ras homolog gene family, member G (rho G)|rho-related GTP-binding protein RhoG
Swissprots P35238 Q8NI04 P84095
Accessions EAX02575 EAX02576 EAX02577 P84095 AA424888 AF498974 AAM21121 AY563952 AAS75333 BC104177 AAI04178 BC104178 AAI04179 BI196968 BT019872 AAV38675 BX359696 CB125569 CR450335 CAG29331 CR542105 CAG46902 L11317 AAA60268 X61587 CAA43784 XM_005252916 XP_005252973 NM_001665 NP_001656
Function Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742, ECO:0000269|PubMed:20679435}.
Subcellular Location Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Top Pathways Bacterial invasion of epithelial cells, Salmonella infection