Trxr-1

Gene Symbol Trxr-1
Entrez Gene 31760
Alt Symbol 2151, CG2151, DTR, Dm-TrxR, DmTR, DmTrx, DmTrxR, DmTrxR-1, Dmel\CG2151, GR, Gr, TH, TRR, Trx, TrxR, TrxR-1, Trxr1, anon-WO03040301.185, anon-WO03040301.187, dTrxR, dmtrxr-1, gr, l(1)G0154, l(1)G0379, l(1)G0477, l(1)G0481, trxr-1
Species Drosophila
Gene Type protein-coding
Description Thioredoxin reductase-1
Other Description CG2151-PA|CG2151-PB|CG2151-PC|Trxr-1-PA|Trxr-1-PB|Trxr-1-PC|disulfide reductase|glutathione reductase|thioredoxin reductase|thioredoxin reductase-1
Swissprots Q9W3H2 Q1RKZ0 P91938 Q9W3H3 Q961E3 Q53YG2
Accessions AAF46354 AAF46355 AAN09228 P91938 AF301144 AAG25639 BT003266 AAO25023 BT025070 ABE73241 NM_078527 NP_511082 NM_167149 NP_727251 NM_167150 NP_727252
Function Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms. {ECO:0000269|PubMed:11158675, ECO:0000269|PubMed:11525742, ECO:0000269|PubMed:11796729}.
Subcellular Location Isoform B: Mitochondrion.
Tissue Specificity During embryogenesis, expression is seen in germ cell progenitors, developing midgut, hindgut and proventriculus. {ECO:0000269|PubMed:11525742}.
Top Pathways Selenocompound metabolism, Pyrimidine metabolism