GOT2

Gene Symbol GOT2
Entrez Gene 2806
Alt Symbol KAT4, KATIV, mitAAT
Species Human
Gene Type protein-coding
Description glutamic-oxaloacetic transaminase 2, mitochondrial
Other Description FABP-1|FABPpm|aspartate aminotransferase 2|aspartate aminotransferase, mitochondrial|aspartate transaminase 2|fatty acid-binding protein|glutamate oxaloacetate transaminase 2|glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)|kynurenine aminotransferase 4|kynurenine aminotransferase IV|kynurenine--oxoglutarate transaminase 4|kynurenine--oxoglutarate transaminase IV|mAspAT|plasma membrane-associated fatty acid-binding protein|transaminase A
Swissprots Q53FL3 Q9BWA3 E7ERW2 B4DJA6 P00505
Accessions EAW82988 EAW82989 P00505 AK098313 BAG53610 AK223271 BAD96991 AK290847 BAF83536 AK295993 BAG58768 AK302249 BAG63601 AK307598 AL516773 BC000525 AAH00525 BI667777 DB485399 DQ891883 ABM82809 DQ895068 ABM85994 M22632 AAA35568 NM_001286220 NP_001273149 NM_002080 NP_002071
Function Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:9537447}.
Subcellular Location Mitochondrion matrix {ECO:0000269|PubMed:9537447}. Cell membrane {ECO:0000269|PubMed:9537447}. Note=Exposure to alcohol promotes translocation to the cell membrane.
Top Pathways Cysteine and methionine metabolism, Fat digestion and absorption, Alanine, aspartate and glutamate metabolism, 2-Oxocarboxylic acid metabolism, Carbon metabolism