PPT2

Gene Symbol PPT2
Entrez Gene 9374
Alt Symbol C6orf8, G14, PPT-2
Species Human
Gene Type protein-coding
Description palmitoyl-protein thioesterase 2
Other Description S-thioesterase G14|VE-statin2|lysosomal thioesterase PPT2|palmitoyl-protein hydrolase 2
Swissprots Q5JQF0 G8JLE1 A8K9L4 Q5STJ6 Q99945 A2BFI2 Q5SSX6 Q9UMR5 Q5SSX4 A2ABC9 A2BFH7 A2BFH9 O14799 Q5JP14 A2ARM7 B0S868 Q5JP13 Q5STJ5 Q6FI80 Q5SSX5 Q5STJ4 A2ABD1 Q0P6K0
Accessions AAB47495 EAX03591 EAX03592 EAX03593 EAX03594 EAX03595 EAX03596 Q9UMR5 AF020543 AAB80730 AI472281 AL110128 CAB53659 AM392834 CAL37712 BC000955 BC001355 AAH01355 CR533546 CAG38577 DA153675 DA352776 DA918701 EU832333 ACE87590 EU832418 ACE86903 Y17958 CAB46981 NM_001204103 NP_001191032 NM_005155 NP_005146 NM_138717 NP_619731 NM_138934
Function Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S- thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins. {ECO:0000269|PubMed:10417332, ECO:0000269|PubMed:12855696, ECO:0000269|PubMed:9341199}.
Subcellular Location Lysosome {ECO:0000269|PubMed:9341199}.
Tissue Specificity Broadly expressed, with highest levels in skeletal muscle. {ECO:0000269|PubMed:9341199}.
Top Pathways Lysosome, Fatty acid elongation, Fatty acid metabolism