GLUL

Gene Symbol GLUL
Entrez Gene 2752
Alt Symbol GLNS, GS, PIG43, PIG59
Species Human
Gene Type protein-coding
Description glutamate-ammonia ligase
Other Description cell proliferation-inducing protein 59|glutamate decarboxylase|glutamine synthase|glutamine synthetase|proliferation-inducing protein 43
Swissprots Q7Z3W4 Q8IZ17 Q499Y9 Q5T9Z1 P15104
Accessions AAS57905 CCD35254 EAW91116 EAW91117 EAW91118 EAW91119 EAW91120 EAW91121 EAW91122 P15104 AI147221 AI286093 AK092874 BAG52617 AK122784 BAG53728 AK301600 BAG63088 AL161952 CAB82304 AW665656 AW954632 AY486122 AAS57904 AY513283 AAT08036 AY947343 AAY57874 BC010037 AAH10037 BC011700 AAH11700 BC011852 AAH11852 BC018992 AAH18992 BC031964 AAH31964 BC051726 AAH51726 BC127883 AAI27884 BF923451 BG771732 BI668874 BM662182 BM690132 BQ637044 BX537384 CAD97626 CD300750 CD688156 DA151535 DA322310 DA456371 DB317032 DQ893278 ABM84204 DQ896609 ABM87608 EU832658 ACE87749 EU832735 ACE87067 S70290 AAB30693 X59834 CAA42495 Y00387 CAA68457 XM_006711278 XP_006711341 NM_001033044 NP_001028216 NM_001033056 NP_001028228 NM_002065 NP_002056
Function This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts. {ECO:0000250, ECO:0000269|PubMed:18662667}.
Subcellular Location Cytoplasm. Mitochondrion {ECO:0000250}.
Top Pathways Nitrogen metabolism, GABAergic synapse, Glutamatergic synapse, Arginine and proline metabolism, Glyoxylate and dicarboxylate metabolism