| Gene Symbol | MAPK8 |
|---|---|
| Entrez Gene | 5599 |
| Alt Symbol | JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c |
| Species | Human |
| Gene Type | protein-coding |
| Description | mitogen-activated protein kinase 8 |
| Other Description | JUN N-terminal kinase|MAP kinase 8|c-Jun N-terminal kinase 1|mitogen-activated protein kinase 8 isoform JNK1 alpha1|mitogen-activated protein kinase 8 isoform JNK1 beta2|stress-activated protein kinase 1|stress-activated protein kinase 1c |
| Swissprots | P45983 Q308M2 D3DX92 Q15712 B5BTZ5 B7ZLV4 D3DX88 Q15709 Q15713 |
| Accessions | EAW93129 EAW93130 EAW93131 EAW93132 EAW93133 EAW93134 EAW93135 EAW93136 EAW93137 EAW93138 P45983 AA808177 AB074280 AB451231 BAG70045 AB451271 BAG70085 AB451354 BAG70168 AB451398 BAG70212 AK094000 AK125150 AK292523 BAF85212 AL137667 BC130570 AAI30571 BC130572 AAI30573 BC144063 AAI44064 DA159335 DQ234352 ABB29981 HQ258413 ADR83167 L26318 AAA36131 U34822 AAC50607 U35004 AAC50610 U35005 AAC50611 XM_011539953 XP_011538255 XM_011539954 XP_011538256 XM_011539955 XP_011538257 XM_011539956 XP_011538258 XM_011539957 XP_011538259 XM_011539958 XP_011538260 NM_001278547 NP_001265476 NM_001278548 NP_001265477 NM_002750 NP_002741 NM_139046 NP_620634 NM_139049 NP_620637 |
| Function | Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:21148294}. Nucleus {ECO:0000269|PubMed:21148294}. |
| Top Pathways | Inflammatory mediator regulation of TRP channels, Sphingolipid signaling pathway, Herpes simplex infection, Dopaminergic synapse, Choline metabolism in cancer |