| Gene Symbol | PLA2G4A |
|---|---|
| Entrez Gene | 100033889 |
| Alt Symbol | PLA2, PLA2G1B |
| Species | Horse |
| Gene Type | protein-coding |
| Description | phospholipase A2, group IVA (cytosolic, calcium-dependent) |
| Other Description | cPLA2|cytosolic phospholipase A2|phospholipase A2 group IVA|phospholipase A2, group IB (pancreas) |
| Swissprots | O77793 |
| Accessions | O77793 AF092539 AAC61774 XM_005609738 XP_005609795 XM_005609739 XP_005609796 XM_005609740 XP_005609797 XM_005609741 XP_005609798 XM_005609742 XP_005609799 NM_001081843 NP_001075312 |
| Function | Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Translocates to membrane vesicles in a calcium-dependent fashion. {ECO:0000250}. |
| Top Pathways | Glutamatergic synapse, Choline metabolism in cancer, Oxytocin signaling pathway, Inflammatory mediator regulation of TRP channels, VEGF signaling pathway |