| Gene Symbol | ACSL5 |
|---|---|
| Entrez Gene | 51703 |
| Alt Symbol | ACS2, ACS5, FACL5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | acyl-CoA synthetase long-chain family member 5 |
| Other Description | FACL5 for fatty acid coenzyme A ligase 5|LACS 5|fatty acid coenzyme A ligase 5|fatty-acid-Coenzyme A ligase, long-chain 5|long-chain acyl-CoA synthetase 5|long-chain fatty acid coenzyme A ligase 5|long-chain-fatty-acid--CoA ligase 5 |
| Swissprots | Q9UIU4 D3DRB3 Q6UX44 A6GV77 Q9ULC5 |
| Accessions | BAA86054 CAC79123 CAJ56749 EAW49532 EAW49533 EAW49534 EAW49535 EAW49536 EAW49537 EAW49538 EAW49539 Q9ULC5 AB033899 BAA85979 AJ496489 CAD43000 AK000339 AK024932 AK222782 AK223288 AK301786 BAG63242 AK310436 AL708480 AM262166 CAK18174 AY358520 AAQ88884 BC007985 AAH07985 CD689921 CF595490 DQ893266 ABM84192 DQ896596 ABM87595 NM_016234 NP_057318 NM_203379 NP_976313 NM_203380 NP_976314 |
| Function | Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. {ECO:0000250, ECO:0000269|PubMed:17681178, ECO:0000269|PubMed:18806831, ECO:0000269|PubMed:19459852}. |
| Subcellular Location | Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. |
| Top Pathways | Adipocytokine signaling pathway, PPAR signaling pathway, Peroxisome, Fatty acid biosynthesis, Fatty acid degradation |