Msh2

Gene Symbol Msh2
Entrez Gene 17685
Alt Symbol AI788990
Species Mouse
Gene Type protein-coding
Description mutS homolog 2 (E. coli)
Other Description DNA mismatch repair protein Msh2|mutS protein homolog 2
Swissprots P43247
Accessions EDL38635 P43247 AK051960 AK078775 AK157842 BAE34223 AK166179 AK206893 AK216255 AK217675 BC047117 AAH47117 BC050897 AAH50897 U21011 AAA75027 X81143 CAA57049 NM_008628 NP_032654
Function Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2- MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformationa
Subcellular Location Nucleus {ECO:0000305}.
Top Pathways Mismatch repair, Colorectal cancer